Impotent Drugs May Affect the Motility Sperm

Impotent drugs used to treat erectile dysfunction may have improved sex lives of men around the world, but a new study conducted in the laboratory suggests that such drugs can have a negative effect in sperm motility, or the ability of the sperm to move freely through the female reproductive tract. Due to the need that the sperm must “swim” to reach and fertilize the egg in the female reproductive tract, the findings raise new questions now about the effect of these drugs on male fertility.

Results of the study shows that sildenafil (better known as Viagra) or other drugs are injected directly into the penis, such as Phentolamine can reduce the motility of sperm, according to the American Journal of Obstetrics and Gynecology Dr. J Roberto Andrade, an obstetrician and gynecologist at the Union Memorial Hospital in Baltimore, Maryland. Dr. Andrade was straight to the point by saying that the study was on small sperm samples in the laboratory and therefore this cannot happen in the similar way inside our body, given the conditions of the human body. The study was done using samples from 10 men aged 18-44 years.

While both drugs in high concentrations end up affecting sperm motility, research in turn was not performed under ideal conditions, reports Dr. Andrade to Reuters Health. “We try to isolate the molecule Viagra but could not do so in pH that would likely be found in natural conditions, instead the researchers ended up mixing Viagra and sperm at low pH.” A dose of 200 micrograms has no effect on motility of spermatozoa, but the dose 2000 microgram reduces the motility by 50% according to the results presented. These are well below the doses that men take, though the drug found in sperm is quite diluted, noted Dr. Andrade. Still, this was not the expected result, since he anticipated that Viagra could even accelerate motility sperm. I thought just the opposite," commented Dr. Andrade while talking to Reuters Health.

The effect of Phentolamine was expected because more is known that the drug inhibits androgen receptors. A dose of 20 micrograms has no effect; however, with 200 micrograms mixed with sperm “results in a significant reduction in sperm motility.” With 2000 micrograms almost all the sperm stopped along the way. In fact, people are very curious about this study. No one until the research thought the sperm quality and its motility will be affected while using drugs to treat erectile dysfunction.  While most men who take these drugs are older and perhaps therefore less concerned with the issue of fertility, there are also young men who are doing fertility treatment. Men only think of order Viagra and take it, never realised that it will affect their fertility.

The study was unable to determine the exact concentration of the drugs found in sperm. “Clinical studies must be undertaken to assess the concentration of these drugs in the sperm necessary for the restoration of erectile function, but also to determine how these drugs affect the quality and quantity of sperm and fertility ultimately”, concluded Dr. Andrade and his team. They plan to study the effect of these drugs on sperm motility directly in human models. “While these results are still preliminary, if a couple has experienced fertility problems while man is using drugs for the treatment of impotent, his doctor should be consulted”, advises the researcher.

Natural Alternatives to Treat Erectile Dysfunction

We have studied the effect of some herbs for erectile dysfunction, although much less than drug treatments as "Levitra" (Levitra®), the "sildenafil" (Viagra®) and "tadalafil" (Cialis®). In the market for herbal medicines are offered various options that appear to perform miracles, and have been used by ancient cultures like Chinese, African and Indian. Here is what the scientific evidence has confirmed so far.

The following products are sold in health food stores supplements without a prescription, and have shown qualities to treat erectile dysfunction. Although a substance is "natural" should be used cautiously. Consult your doctor before taking any herbal or herbal sexual enhancer, as they may have side effects when interact with other medicines.

Here we explain clearly their characteristics and common precautions to consider when eating. For clarity, only mentioned are precautions that apply to men and have left out those unique to women.

Ginseng (Panax ginseng)

The Chinese or Korean ginseng (Panax ginseng) is a plant whose root is used medicinally. Not to be confused with American ginseng and Siberian, it has been used by traditional Chinese as a medicine for over 2000 years.

The Panax ginseng in combination with Ginkgo biloba has been shown to be effective in improving memory and thinking skills (abstract, arithmetic and reaction rate) in middle age. There is also evidence that it lowers blood sugar levels in diabetics and improves sexual function in men with erectile dysfunction. It also helps to stop premature ejaculation in a cream applied to the penis.

Precautions before taking Panax ginseng:

·         It can cause insomnia in people who have difficulty falling asleep.

·         If you have heart problems, it may slightly increase your heart rate and pressure on the first day you use it. Usually, no changes when ingested regularly. However, it is important to consume the Panax ginseng with caution since its effects has not been studied in people with cardiovascular disease.

·         Do not use if you have any bleeding since it interferes with blood clotting.

·         It can reduce levels of blood sugar. People with diabetes who are also taking medication to lower blood sugar should monitor their blood sugar levels, so that they do not fall more than necessary.

·         It increases the activity of the immune system, therefore, may worsen autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis and lupus, among others. Do not use Panax ginseng if you suffer from any of these health conditions.

·         Do not use it if you have received an organ transplant, as it may interfere with medications prescribed to accept the body.

DHEA

DHEA (dehydroepiandrosterone) is a hormone that occurs naturally in the human body by the adrenal glands, responsible for helping the body to handle stress. The DHEA serves as precursor to male and female sex hormones, and their levels begin to decline after age 30. It also decreases the concerns and lack of joy.

There is evidence that DHEA is effective for treating osteoporosis, improve the appearance of skin in older people, improve lupus, treat schizophrenia and improve erectile dysfunction. Its effect is greater in cases of erectile dysfunction that are not caused by diabetes or by disorders of the nervous system.

Precautions before taking DHEA:

·         It is a safe alternative when taken in small doses (25 to 50 mg daily or every other day) and for short periods of time. Do not consume higher doses 50-100 mg for long periods of time because they may increase its side effects.

·         Do not use if you have liver problems, as they may worsen.

·         If you have diabetes, you should monitor your blood sugar carefully as DHEA can affect how insulin works in the body.

·         The DHEA may decrease the levels of “Good” cholesterol (High Lipoprotein Cholesterol - HDL). It is important to consult your doctor before taking DHEA if you have cholesterol problems.

·         It can cause depression, irritability and impulsivity. Pay attention to any changes in your mood.

·         Men who suffer from hormone-related cancers, such as prostate cancer should not take DHEA supplements.

L-arginine

The L-arginine is an amino acid found in foods like nuts and other seeds, red meat, poultry birds, fish and dairy products. It is necessary for the production of proteins in the body. It can also be consumed in the form of nutritional supplements, although generally the body makes all the L-arginine you need.

This amino acid is effective in treating erectile dysfunction, as it opens blood vessels and improves the flow in them. It has also worked well in other health conditions, such as symptoms and pains of angina, heart failure, fluid congestion and inflammation of the bladder. It also helps reduce infections and closing wounds after surgery.

Precautions before taking L-arginine:

·         It's safe when taken for short periods of time. Some of their side effects may include nausea, diarrhoea and cramps.

·         Do not take supplements of L-arginine along with drugs like Viagra®.

·         Use cautiously as it can cause allergic responses or worsen inflammation of the airways.

·         It could cause problems for people suffering from low blood pressure.

·         If you have had a heart attack recently, never ingest it because it increases the risk of death after a heart attack, especially in older people.

·         There is some evidence that L-arginine may worsen the herpes virus.

·         One must stop their consumption at least two weeks before surgery, since it affects blood pressure and may interfere with their control during and after surgery.

Erectile Dysfunction and Diabetes Mellitus

Erectile dysfunction is the complication related to getting and maintaining a penile erection sufficient for penetration during sex. Erectile Dysfunction (ED) is therefore different from the problem of lack of sexual desire or premature ejaculation. Men with ED have sexual desire, but are unable to get or keep an erection.

Men with diabetes have a much easier time developing ED than men without the disease. And they develop for 5 to 10 years earlier and 25 to 75% more than a human without diabetes. According to the American Diabetes Association, at least half of men over 50 who have diabetes also suffer from ED. Risk of ED increases depending on how many years the man is with diabetes and their severity. Yet, the ED of men with diabetes can be well controlled with proper medication and treatment.

How man achieves erection?

Erections occur as a result of physical and / or psychological stimuli that cause the blood to flow and fill the tissue as sponge (called corpora cavernosa) of the penis. There is an artery running through the center of each corpus cavernosum. When there is an excitement, the body transmits chemical messages to the brain which in return signals the body’s smooth muscle cells to relax. When this occurs, blood is trapped there by the outer layer of the corpora cavernosa that causes it to not quit and be filled with blood and finally an erection. When the excitement is over, or the man has orgasm, the cells of the corpora cavernosa contract sending blood out of it.

Why men with diabetes have erectile dysfunction risk?

Men with diabetes have three main risk factors for having ED. First, diabetes can cause nerve damage (neuropathy) throughout the body, including the nerves of the penis. Changes in penile nerves can interfere with the ability of your body to send messages and receive them in the penis. Diabetes can worsen the condition known as atherosclerosis, in which the blood flows with difficulty by blood vessels. The narrowing of vessels of the penis, which are much thinner than those around the heart, causes an input difficulty and blood out of the penis, causing ED. Finally, diabetic men must monitor their blood glucose. 

When not controlled, your body does not produce enough nitric oxide and vascular tissues do not respond well. Nitric oxide (NO) is a neurotransmitter produced by the body, responsible for helping the communication of a cell with the other. If the body does not produce enough Nitric oxide, the veins of the penis are not compressed with pressure and the blood comes out quickly with no hard erection. In addition to these causes, men with diabetes often have other associated conditions with ED - including hypertension, obesity and increased triglycerides and cholesterol. In general, diabetic patients have more than one adjuvant cause that does develop ED.

How to treat erectile dysfunction in who is diabetes?

The first ED treatment rule for diabetic patient is to control the sugar level in blood. Your doctor most likely will recommend some changes in your lifestyle as changing your diet and increase your physical activity.

Treatment:

1-    Changes in lifestyle: diet change, increased physical activity, weight loss, stop smoking.

2-    Medicines for diabetes, for other diseases, pro-erection medication (Levitra, Levitra, Cialis, Viagra).

3-    Other treatment options: therapy injection into the penis, vacuum use, therapy with androgens.

To sum up

Erectile dysfunction does not necessarily occur in all men who have diabetes mellitus. Keep your blood glucose (blood sugar) well controlled and have a healthy lifestyle to reduce the risk of ED. Control other associated diseases such as heart disease and hypertension. But it is very important that the man regularly consult the doctor, even if you have not yet ED signals.